Anxiety of SART-stressed mice in an elevated plus-maze and drug effects
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منابع مشابه
Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze
Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...
متن کاملmodulation of anxiety-like behavior in sildenafil citrate-treated mice placed in an elevated plus-maze
introduction: sildenafil, a phosphodiesterase-5 (pde5) inhibitor, may have various effects on the central nervous system via the nitric oxide (no)-cyclic guanosine monophosphate (cgmp) pathway. preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. this study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...
متن کاملElevated Plus Maze for Mice
Although the mouse genome is now completely sequenced, the functions of most of the genes expressed in the brain are not known. The influence of a given gene on a specific behavior can be determined by behavioral analysis of mutant mice. If a target gene is expressed in the brain, behavioral phenotype of the mutant mice could elucidate the genetic mechanism of normal behaviors. The elevated plu...
متن کاملModulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze
smooth muscles, and therefore, improved erection (McCullough, 2002; Ulhayathas et al., 2007). Evidence shows that sildenafil inhibits cGMP degradation in the brain (Hotchkiss et al., 2005; Riazi et al., 2006) and affects the central nervous system (Ulhayathas et al., 2007). In the NO-cGMP pathway, sildenafil modulates cognition, memory, reward-related stimuli, pain perception, seizure attack, n...
متن کاملMemory-impairing effects of local anesthetics in an elevated plus-maze test in mice.
Post-training intracerebroventricular administration of procaine (20 micrograms/microliter) and dimethocaine (10 or 20 micrograms/microliter), local anesthetics of the ester class, prolonged the latency (s) in the retention test of male and female 3-month-old Swiss albino mice (25-35 g body weight; N = 140) in the elevated plus-maze (mean +/- SEM for 10 male mice: control = 41.2 +/- 8.1; procai...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1999
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)34979-0